In an adaptive clinical trial , key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also may involve ethical considerations that differ from more traditional randomized trials. Better understanding of clinical trial experts’ views about the ethical aspects of adaptive designs could assist those planning ACTs. Our aim was to elucidate the opinions of clinical (...) trial experts regarding their beliefs about ethical aspects of ACTs. (shrink)

Machine generated contents note: 1. -- War on war, by Lewis Thomas -- 2. -- Silent genocide, by Abdus Salam -- 3. -- Error: a stage of knowledge, by Paulo Freire -- 4. -- Doing without a revolution?, by Tahar Ben Jelloun -- 5. -- Stop torture, by Manfred Nowak -- 6. -- Truth, force and law, by Rabindranath Tagore -- 7. -- Violence is an insult to the human being, by Federico Mayor -- 8. -- Totalitarianism banishes politics, (...) by Vaclav Havel -- 9. -- No one will stop us. , by Desmond Tutu -- 10. -- Colonialism and the youth bomb, by Joseph Ki-Zerbo -- 11. -- The shedding of blood -- 12. -- Letter from Nagasaki, by Takashi Nagai -- 13. -- Down with exclusion!, by Herbert de Souza -- 14. -- The nower to sav 'no'. bv loan Martin-Brown -- 15. -- Inquiry into a taboo, by Ouassila Si Saber -- 16. -- The illusions of rationalism, by Ernesto Sabato -- 17. -- The 'poisonous weed', by Ba Jin -- 18. -- Humanity, an ongoing creation, by Ali Ahmad Said Esber (Adonis) -- 19. -- Image, writing and the vandal, by Alberto Moravia -- 20. -- The charms of calumny, by Andres Bello -- 21. -- On the threshold of eternity, by the Abbe Pierre -- 22. -- The control of force, by Karl Jaspers -- 23. -- The nature of force, by Simone Weil -- 24. -- The debt of justice, by Martin Luther King -- 25. -- Democracy and barbarism, by Sergei S. Averintsev -- 26. -- If all the animals should disappear, by Richard Fitter -- 27. -- Irony and compassion, by Octavio Paz -- 28. -- Against all hatred, by Aime Cesaire -- 29. -- Creating differences, by Daniel J. Boorstin -- 30. -- I dislike the word 'tolerance', by Mahatma Gandhi. (shrink)

This Is A New Release Of The Original 1903 Edition.

The traditional college student of today is part of the Net Generation who has been raised in an era of instant access. Their communication and learning is complemented by the Internet, a major influence on this cohort. The regular method of contact is text messaging, instant messaging and cell phones. Learning methods for the Net Generation include Internet tools such as Web-CT, Blackboard, online courses, online journals and i-pod downloads. Are they ready to also change from print textbooks to Internet (...) based textbooks? This paper describes the attitudes of some Net Generation students towards the usage of electronic textbooks. Three case studies were conducted: one class used an online textbook and two other classes used e-chapter supplements. Students were questioned on their perceptions of using and learning with e-textbooks. Their views describe some changing thoughts towards network connected media that is the mantra of this generation. (shrink)

Despite its strengths, Leech et al.'s model fails to address the important benefits that derive from self-explanation and task feedback in analogical reasoning development. These components encourage explicit, self-reflective processes that do not necessarily link to knowledge accretion. We wonder, therefore, what mechanisms can be included within a connectionist framework to model self-reflective involvement and its beneficial consequences.

As biological and biomedical research increasingly reference the environmental context of the biological entities under study, the need for formalisation and standardisation of environment descriptors is growing. The Environment Ontology (ENVO) is a community-led, open project which seeks to provide an ontology for specifying a wide range of environments relevant to multiple life science disciplines and, through an open participation model, to accommodate the terminological requirements of all those needing to annotate data using ontology classes. This paper summarises ENVO’s motivation, (...) content, structure, adoption, and governance approach. (shrink)

This article addresses five research questions: What specific behaviors are described in the literature as ethical or unethical? What percentage of business people are believed to be guilty of unethical behavior? What specific unethical behaviors have been observed by bank employees? How serious are the behaviors? Are experiences and attitudes affected by demographics? Conclusions suggest: There are seventeen categories of behavior, and that they are heavily skewed toward internal behaviors. Younger employees have a higher level of ethical consciousness than older (...) employees. The longer one works for a company, the more one may look to job security as a priority; this can lead to rationalizing or overlooking apparently unethical behaviors. More emphasis is needed on internal behaviors with particular attention on the impact that external behaviors have on internal behaviors. (shrink)

Two articles by Lewis Feuer caught my attention in the '40s when 1 was wondering, asa student physicist, about the relations of physics to philosophy and to the world in turmoil. One was his essay on 'The Development of Logical Empiricism' (1941), and the other his critical review of Philipp Frank's biography of Einstein, 'Philosophy and the Theory of Relativity' (1947). How extraordinary it was to find so intelligent, independent, critical, and humane a mind; and furthermore he went further, (...) as I soon realized when I looked for his name on other publications. I recall arguing with myself over his exploration of 'Indeterminacy and Economic Development' (1948), and even more when I read his 'Dialectical Materialism and Soviet Science' (1949). More papers, and then the fascinating, sometimes irritating, always insightful, books. His monograph on Psychoanalysis and Ethics 1955, the beautiful sociological and humanist study of Spinoza and the Rise of Liberalism (1958), his essays on 'The Social Roots of Einstein's Theory of Relativity' (1971) together with the book on Einstein and the Genera tions of Science (1974), the splendid reader from the works of Marx and Engels, Basic Writings on Politics and Philosophy (1959) which was a major text of the '60s, the stimulating essays on the social formation which seems to have been required for a modern scientific movement to develop, set forth most convincingly in The Scientific Intellectual (1963). (shrink)

This book, sure to become a standard reference work, is a comprehensive, lucid, and systematic commentary on Kant's practical philosophy. Kant is arguably the most important moral philosopher of the modern period. Using as nontechnical a language as possible, Professor Sullivan offers a detailed, authoritative account of Kant's moral philosophy - including his ethical theory, his philosophy of history, his political philosophy, his philosophy of religion, and his philosophy of education - and demonstrates the historical, Kantian origins of such important (...) notions as 'autonomy', 'respect for persons', 'rights', and 'duties'. An invaluable resource, this book will be extremely useful to advanced undergraduates, graduates, and professional philosophers alike. (shrink)

This is the most up-to-date, brief and accessible introduction to Kant's ethics available. It approaches the moral theory via the political philosophy, thus allowing the reader to appreciate why Kant argued that the legal structure for any civil society must have a moral basis. This approach also explains why Kant thought that our basic moral norms should serve as laws of conduct for everyone. The volume includes a detailed commentary on Foundations of the Metaphysics of Morals, Kant's most widely studied (...) work of moral philosophy. The book complements the author's much more comprehensive and systematic study Immanuel Kant's Moral Theory, a volume that has received the highest critical praise. With its briefer compass and non-technical style this new introduction should help to disseminate the key elements of one of the great modern philosophies to an even wider readership. (shrink)

In this Volume, published in1998, Fifteen scholars reveal the ways of preserving, conceiving and creating beauty were as diverse as the cultural influenced at work at the time, deriving from antique, medieval and more recent literature and philosophy, and from contemporary notions of morality and courtly behaviour. Approaches include discussion of contemporary critical terms and how these determined writers' appreciation of paintings, sculpture, architecture and costume; studies of the quest to create beauty in the work of artists such as Botticeli, (...) Leonardo, Raphael, Parmigianino and Vasari; and the investigation of changes functioning of the eye and brain, or to technical innovations like those found in Venetian glass. (shrink)

I defend the view that the design of the built environment should be a proper part of environmental ethics. An environmentally responsible culture should be one in which citizens take responsibility for the domesticated environments in which they live, as well as for their effects on wild nature. How we build our world reveals both the possibilities in nature and our own stance toward the world. Our constructions and contrivances also objectively constrain the possibilities for the development of a human (...) way of life integrated with wild nature. An environmentally responsible culture should require a built world that reflects and projects care and respect toward nature. (shrink)

Efforts to bring science into early 19th century breeding practices in Central Europe, organised from Brno, the Hapsburg city in which Mendel would later turn breeding experiments into a body of timeless theory, are here considered as a significant prelude to the great discovery. During those years prior to Mendel's arrival in Brno, enlightened breeders were seeking ways to regulate the process of heredity, which they viewed as a force to be controlled. Many were specialising in sheep breeding for the (...) benefit of the local wool industry while others were showing an interest in commercial plants, especially fruit trees and vines, and later cereals. Breeders explained their problems in regulating heredity in terms of climatic influences disruption due to crossing sports or saltations. Practical experience led them to the concepts of 'inheritance capacity' and the 'mutual elective affinity' of parents. The former was seen to differ among individuals and also among traits; the latter was proposed as a means of adding strength to heredity. The breeders came to recognise that traits might be hidden and yet transmitted as a 'potential' to future generations. They also grew to understand that heredity would be strengthened when a quality was 'fixed' within a lineage by 'pure blood relations.' Continued selection of the desired quality might then lead to 'a higher perfection.' But the ultimate 'physiological' question about breeding, 'what is inherited and how?,' found no answer. Major figures in this development included Abbot Napp, the one who asked this question and who was due to receive Mendel into the monastery in 1843, and Professor Diebl whose lectures on agriculture and natural science at the Brno Philosophical Institute Mendel would attend in 1846. Here we analyse their progress in theorizing about breeding up until about 1840. In discussing this development, we refer to certain international contacts, especially with respect to information transfer and scientific education, within the wider context of the late Enlightenment. (shrink)

Sleep enhances integration across multiple stimuli, abstraction of general rules, insight into hidden solutions and false memory formation. Newly learned information is better assimilated if compatible with an existing cognitive framework or schema. This article proposes a mechanism by which the reactivation of newly learned memories during sleep could actively underpin both schema formation and the addition of new knowledge to existing schemata. Under this model, the overlapping replay of related memories selectively strengthens shared elements. Repeated reactivation of memories in (...) different combinations progressively builds schematic representations of the relationships between stimuli. We argue that this selective strengthening forms the basis of cognitive abstraction, and explain how it facilitates insight and false memory formation. (shrink)

This essay articulates the importance of the domesticated landscape for a mature environmental ethics. Human beings are spatial beings, deeply implicated in their relationships to places, both wild and domesticated. Human identity evolves contextually through interaction with a "world." If this world obscures our perception of wild nature, it will be difficult to motivate the social and psychological will to imagine, let alone participate in, a culture that values environmentally responsible conduct. My argument is informed by a pragmatist suspicion of (...) fixed dualisms separating humans from nature, the wild from the domesticated, and the natural from the artificial. Drawing on a variety of sources, the essay calls for greater attention to the ways in which the making of our domesticated worlds can contribute to or undermine our ability to take the intrinsic value of nature seriously. (shrink)

Hunting is a complex phenomenon. l examine it from four different perspectives-animal liberation, the land ethic, primitivism, and ecofeminism-and find no moral justification for sport hunting in any of them. At the same time, however, I argue that there are theoretical flaws in each of these approaches. Animal liberationists focus too much on the individual animal and ignore the difference between domestic and wild animals. Leopold’s land ethic fails to come to terms with the self-domestication of humans. I argue that (...) the holism of the land ethic does not in itself justify hunting as a human act of predation appropriate to the demands of wild biotic communities. Primitivists, such as Paul Shepard and Ortega y Gasset, mistakenly argue that hunting is an essential part of human nature and hence part of a healthy return to a natural way of life. Their argument marginalizes women’s relations to nature. Finally, I take seriously the ecofeminist claim that sport hunting is a symptom ofpatriarchy’s fixation on death and violence, although I criticize the more radical claim that women are closer to nature than men. Hunting should be investigated within the broader context of patriarchal social relations between men and women. As an act of violence it constitutes one element of a cultural matrix which is destructive to hoth women and nature. (shrink)

I will conclude that the Kantian analyses of Aristotle’s moral theory are historically inaccurate and the criticisms invalid. Further, those criticisms are focused in such a way that they tend to distract us from more fundamental issues, especially the different ontologies presupposed in each theory. If my arguments are sound, they show that much of Kant’s moral philosophy is not as novel as he believed it to be nor as it generally has been taken to be.

ONE Wholes and Parts: Introductory Survey COMMON WISDOM ABOUT THE WORLD GUIDES us WELL in daily living, but getting along practically is not enough; ...

1. The Modern Context for a Healing Profession Roger J. Bulger The future of the profession of medicine in America is, at the very least, under serious ...

In this essay I examine the relevance of the vocabulary of an ethics of care to ecofeminism. While this vocabulary appears to offer a promising alternative to moral extensionism and deep ecology, there are problems with the use of this vocabulary by both essentialists and conceptualists. I argue that too great a reliance is placed on personal lived experience as a basis for ecofeminist ethics and that the concept of care is insufficiently determinate to explicate the meaning of care for (...) nature. (shrink)

(1979). Some Observations on the Problems of Grading Examinations with Several Components: a reply to P. J. Squire. Educational Studies: Vol. 5, No. 3, pp. 225-230.